{{ :health:cancer_cure_11_may_2019-1.pdf |Cancer Cure ( PDF ) }} {{ :health:cancer_cure_11_may_2019-1.odt |Cancer Cure ( ODT ) }} ---- Below is a list of psycho-emotional conflicts Dr Ryke Geerd Hamer proposes is the "trigger event" for each different type of cancer in the body. ADRENAL CORTEX: Wrong Direction. Gone Astray BLADDER: Ugly Conflict. Dirty Tricks BONE: Lack of Self Worth. Inferiority Feeling BRAIN TUMOR: Stubbornness. Refusing to Change Old Patterns. Mental Frustration [Dr Hamer does not propose a conflict for brain tumor. The above is Louise Hay's proposed cause.] BREAST MILK GLAND: Involving Care or Disharmony BREAST MILK DUCT: Separation Conflict BREAST LEFT: Conflict concerning Child, Home or Mother BREAST RIGHT: Conflict with Partner or Others BRONCHIOLES: Territorial Conflict CERVIX: Severe Frustration COLON: Ugly Indigestible Conflict ESOPHAGUS: Cannot Have It or Swallow It GALL BLADDER: Rivalry Conflict HEART: Perpetual Conflict INTESTINES: Indigestible Chunk of Anger KIDNEYS: Not wanting to Live. Water or Fluid Conflict LARYNX: Conflict of Fear and Fright LIVER: Fear of Starvation LUNGS: Fear of Dying or Suffocation, including Fear for Someone Else LYMPH GLANDS: Loss of Self-Worth MELANOMA: Feeling Dirty, Soiled, Defiled MIDDLE EAR: Not being able to get some Vital Information MOUTH: Cannot Chew It or Hold It PANCREAS: Anxiety-Anger Conflict with Family Members. Inheritance PROSTATE: Ugly Conflict with Sexual Connotations RECTUM: Fear of Being Useless SKIN: Loss of Integrity SPLEEN: Shock of being Physically/Emotionally Wounded STOMACH: Indigestible Anger. Swallowed Too Much TESTES/OVARIES: Loss Conflict THYROID: Feeling Powerless TUMOR: Nursing Old Hurts and Shocks. Building Remorse [Dr Hamer does not propose a conflict for tumor. The above is Louise Hay's proposed cause.] UTERUS: Sexual Conflict ---- [[https://www.researchgate.net/publication/353887266_Factors_Associated_With_Depression_in_Breast_Cancer_Patients_in_Saudi_Arabia| Factors Associated With Depression in Breast Cancer Patients in Saudi Arabia]] According to the Saudi National Mental Health Survey, some of the most common mental health issues in Saudi Arabia include generalized anxiety disorder, substance use disorder, postpartum depression and psychosis, schizophrenia, intimate partner violence and abuse, obsessive-compulsive disorder, bipolar disorder, and panic disorder. However, the survey does not provide a ranking of these issues. A scoping review published in the Mental Health Review Journal highlights that stigma associated with mental health problems is widespread in Saudi Arabia. This stigma may prevent many Saudi people from accessing the mental health-care services and support they need. [[https://www.nature.com/articles/ncponc0209|Garlic extract and apoptosis in a human cancer cell line]] [[https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21694|Intermittent fasting in the prevention and treatment of cancer]] [[http://globalcancermap.com/|Global Cancer Mortality]] [[https://gis.cdc.gov/Cancer/USCS/#/AtAGlance/|Rate of New Cancers in the United States, 2019]] [[http://www.ncin.org.uk/view?rid=544|The effect of rurality on cancer incidence and mortality]] [[https://www.nature.com/articles/s41698-020-00129-0|Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer]] **Skin cancer** [[https://www.skincancer.org/blog/the-mind-skin-stress-connection/|The Mind-Skin Stress Connection, Part 1]] Reason for skin cancer = Loss of integrity [[https://hospitals.aku.edu/pakistan/diseases-and-conditions/Pages/skin-cancer.aspx|Skin cancer arsenic link]] [[https://www.theladders.com/career-advice/this-is-the-best-way-to-detect-lack-of-integrity-in-others|This is the best way to detect lack of integrity in others]] [[https://www.psychologytoday.com/us/blog/the-workaholics/201110/the-loss-integrity|https://www.psychologytoday.com/us/blog/the-workaholics/201110/the-loss-integrity]] [[https://www.verywellmind.com/integrity-versus-despair-2795738|Integrity vs. Despair in Psychosocial Development]] ---- [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366009/|Garlic and onions: Their cancer prevention properties]] [[https://www.curetoday.com/view/skin-cancer-can-impact-emotional-well-being|Skin Cancer Can Impact Emotional Well-Being]] [[https://www.keckmedicine.org/could-the-cure-to-cancer-be-as-simple-as-drinking-water/| Could the Cure to Cancer be as Simple as Drinking Water?]] [[https://www.healthline.com/health/anxiety/dehydration-and-anxiety|Dehydration and Anxiety: How to Keep Calm and Hydrate On]] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147771/|Drinking plain water is associated with decreased risk of depression and anxiety in adults: Results from a large cross-sectional study]] [[https://pubmed.ncbi.nlm.nih.gov/19818725/| Depression and immunity: a role for T cells? ]] [[https://www.bbc.com/news/health-51182451|Immune discovery 'may treat all cancer']] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037818/pdf/nihms-269073.pdf|Impact of stress on cancer metastasis]] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466429/|Chronic Stress Promotes Cancer Development]] [[http://www.foodworldnews.com/articles/33448/20150821/the-us-government-finally-admits-cannabis-kills-cancer-cells.htm|Cannabis Effects: U.S. Government Finally Admits Cannabis Kills Cancer Cells]] [[https://www.cancer.gov/about-cancer/treatment/cam/patient/cannabis-pdq|Cannabis and Cannabinoids (PDQ®)–Patient Version]] [[https://www.acspineandwellness.com/blog/an-herb-that-kills-cancer-cells-gives-hope-for-a-cure| An Herb that Kills Cancer Cells Gives Hope for a Cure ]] [[https://onlinelibrary.wiley.com/doi/abs/10.1002/9783906390420.ch2|Clinical Status of Cisplatin, Carboplatin, and Other Platinum-Based Antitumor Drugs]] [[https://www.rush.edu/news/5-cancer-treatments-arent-chemotherapy| 5 Cancer Treatments That Aren’t Chemotherapy ]] [[https://www.nature.com/articles/d41586-020-01038-9|Game-changing class of immunotherapy drugs lengthens melanoma survival rates]] [[https://www.nature.com/articles/d41586-020-01038-9|Game-changing class of immunotherapy drugs lengthens melanoma survival rates]] [[https://pubmed.ncbi.nlm.nih.gov/31895405/| Life Expectancy of Adult Survivors of Childhood Cancer Over 3 Decades ]] [[https://www.nature.com/articles/s41587-019-0381-y|Immunotherapy takes aim at exhausted T cells]] [[https://www.healthline.com/health/skin-cancer/immunotherapy-success-rates-for-melanoma|What You Need to Know About Immunotherapy Success Rates for Melanoma]] [[https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21565|Cancer treatment and survivorship statistics, 2019]] [[https://www.webmd.com/cancer/guide/cure-for-cancer|Is There a Cure for Cancer?]] [[https://academic.oup.com/jnci/article/94/8/558/2520144| Systematic Review of Psychological Therapies for Cancer Patients: Overview and Recommendations for Future Research ]] [[https://www.ledevoir.com/documents/pdf/cancer_yale.pdf|Use of Alternative Medicine for Cancer and ItsImpact on Survival]] [[https://pubmed.ncbi.nlm.nih.gov/27626136/| 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer ]] [[https://www.everydayhealth.com/cancer/8-common-cancer-myths.aspx|8 Common Cancer Myths ]] [[https://pubmed.ncbi.nlm.nih.gov/10797344/| Survival of patients with untreated breast cancer ]] [[https://www.medicalnewstoday.com/articles/326031|Survival and chemotherapy success rates for various cancers]] [[https://www.healthline.com/health/surviving-and-thriving-from-cancer-is-possible|How I Didn’t Let Cancer Stop Me from Thriving (All 9 Times)]] [[https://www.webmd.com/lung-cancer/news/20060906/is-chemo-worth-new-test-may-tell| Is Chemo Worth It? New Test May Tell ]] [[https://www.researchgate.net/post/Why-is-the-success-rate-of-chemotherapy-very-low-And-is-it-possible-to-improve-that|Why is the success rate of chemotherapy very low? And is it possible to improve that?]] [[https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.3322/canjclin.34.5.282|Classics in Oncology Survival in Untreated and Treated Cancer]] [[https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/cancer-treatment-and-survivorship-facts-and-figures/cancer-treatment-and-survivorship-facts-and-figures-2019-2021.pdf| [[https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-14-114|The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella Foenum-Graecum ]] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077604/|Exploring the Therapeutic Ability of Fenugreek against Type 2 Diabetes and Breast Cancer Employing Molecular Docking and Molecular Dynamics Simulations]] [[https://www.sciencedirect.com/science/article/pii/B9780128195475000353|Chapter 35 - Lycium barbarum (goji berry), human breast cancer, and antioxidant profile]] [[https://www.medicalnewstoday.com/articles/322693|What are the health benefits of goji berries?]] [[https://pubmed.ncbi.nlm.nih.gov/26525080/| Anticancer effect of ethanol Lycium barbarum (Goji berry) extract on human breast cancer T47D cell line]] [[https://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300613|Goji Berry Fruit Extracts Suppress Proliferation of Triple-Negative Breast Cancer Cells by Inhibiting EGFR-Mediated ERK/MAPK and PI3K/Akt Signaling Pathways]] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/|Anticancer Activities of Nigella Sativa (Black Cumin)]] [[https://www.sciencedirect.com/science/article/pii/S0975947616300389|Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive]] [[https://www.hindawi.com/journals/ecam/2014/724658/|Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways]] [[https://www.bbc.com/future/article/20150306-the-mystery-of-vanishing-cancer|Cancer: The mysterious miracle cases inspiring doctors]] [[https://www.hsph.harvard.edu/magazine/magazine_article/the-cancer-miracle-isnt-a-cure-its-prevention/|The Cancer Miracle Isn’t a Cure.]] [[https://www.hopkinsmedicine.org/news/articles/curing-cancers-once-thought-incurable| Curing Cancers Once Thought Incurable]] Destruction of cancer cells via 100,000 Hz to 300,000 Hz frequencies [[https://www.youtube.com/watch?v=mBL9pS6GMdA|We've Found The Magic Frequency (This Will Revolutionize Our Future)]] finish list from https://link.springer.com/chapter/10.1007/978-3-030-54027-2_4 Al Sinani SS, Eltayeb EA, Coomber BL, Adham SA (2016) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway. Cancer Cell Int 16:11 https://cancerci.biomedcentral.com/articles/10.1186/s12935-016-0287-4 Albensi BC (2019) What is nuclear factor kappa B (NF-kB) doing in and to the Mitochondrion? Front Cell Dev Biol 7:154 https://www.frontiersin.org/articles/10.3389/fcell.2019.00154/full Ashraf MA (2020) Phytochemicals as potential anticancer drugs: time to ponder nature’s bounty. Biomed Res Int 2020:1–7 [[https://www.hindawi.com/journals/bmri/2020/8602879/| Bagchi K, Puri S (1998) Free radicals and antioxidants in health and disease: a review. East Mediterr Health J 4:350–360]] [[https://apps.who.int/iris/bitstream/handle/10665/118217/emhj_1998_4_2_350_360.pdf?sequence=1| Bai T, Dong D-S, Pei L (2014) Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncol Rep 31:2293–2297]] [[https://www.spandidos-publications.com/10.3892/or.2014.3090?text=fulltext| Beckman K, Ames B (1997) Oxidative DNA decay. J Biol Chem. 272:19633–19636]] [[https://www.jbc.org/content/272/32/19633.short| Beier RC (1990) Natural pesticides and bioactive components in foods. Springer Reviews of environmental contamination and toxicology, 47–137]] [[https://link.springer.com/chapter/10.1007/978-1-4612-3366-4_2| Chinni SR, Sarkar FH (2002) Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Cancer Res 8:1228–1236]] [[https://clincancerres.aacrjournals.org/content/8/4/1228.short| Chirumbolo S, Bjørklund G, Lysiuk R, Vella A, Lenchyk L, Upyr T (2018) Targeting cancer with phytochemicals via their fine tuning of the cell survival signaling pathways. Int J Mol Sci 19:3568]] [[https://www.mdpi.com/1422-0067/19/11/3568| Cho YS, Park SY (2014) Harnessing of programmed necrosis for fighting against cancers. Biomol Ther 22:167]] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060077/| Clark R, Lee S-H (2016) Anticancer properties of capsaicin against human cancer. Anticancer Res 36:837–843]] [[https://ar.iiarjournals.org/content/36/3/837.short| Coker-Gurkan A, Bulut D, Genc R, Arisan E-D, Obakan-Yerlikaya P, Palavan-Unsal N (2019) Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-kB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells. Mol Biol Rep 46:355–369]] [[https://link.springer.com/article/10.1007/s11033-018-4479-y| Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E (2007) Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett 246:201–209]] [[https://www.sciencedirect.com/science/article/pii/S0304383506001236| Cragg GM, Newman DJ (2005) Plants as a source of anti-cancer agents. J Ethnopharmacol 100:72–79]] [[https://www.sciencedirect.com/science/article/pii/S0378874105003259| de Giffoni de Carvalho JT, da Silva Baldivia D, Leite DF, de Araújo LCA, de Toledo Espindola PP, Antunes KA, Rocha PS, de Picoli Souza K, dos Santos EL (2019) Medicinal plants from Brazilian cerrado: antioxidant and anticancer potential and protection against chemotherapy oxicity. Oxid Med Cell Longev 1–16]] [[http://downloads.hindawi.com/journals/omcl/2019/3685264.pdf| De La Parra C, Castillo-Pichardo L, Cruz-Collazo A, Cubano L, Redis R, Calin GA, Dharmawardhane S (2016) Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of genistein. Nutr Cancer 68:154–164]] [[https://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1115104| Deng S, Calin GA, Croce CM, Coukos G, Zhang L (2008) Mechanisms of microRNA deregulation in human cancer. Cell Cycle 7:2643–2646]] [[https://www.tandfonline.com/doi/abs/10.4161/cc.7.17.6597| Diederich M, Cerella C (2016) Non-canonical programmed cell death mechanisms triggered by natural compounds. Semin Cancer Biol 40:4–34]] [[https://www.sciencedirect.com/science/article/pii/S1044579X16300219| Dimitrios B (2006) Sources of natural phenolic antioxidants. Trends Food Sci Technol 17:505–512]] [[https://www.sciencedirect.com/science/article/pii/S0924224406001427| Dou H, Shen TJ, Huang L, Shi H, Chen H, Wang Y, Wang T (2017) Curcumin suppresses the colon cancer proliferation by inhibiting Wnt/β-catenin pathways via miR-130a. Front Pharmacol 8:877]] [[https://www.frontiersin.org/articles/10.3389/fphar.2017.00877/full| Dreher D, Junod AF (1996) Role of oxygen free radicals in cancer development. Eur J Cancer 32:30–38]] [[https://www.sciencedirect.com/science/article/pii/0959804995005315| Efferth T (2017) From ancient herb to modern drug: artemisia annua and artemisinin for cancer therapy. Semin Cancer Biol 46:65–83]] [[https://www.sciencedirect.com/science/article/pii/S1044579X17300299| Fulda S (2018) Repurposing anticancer drugs for targeting necroptosis. Cell Cycle 17:829–832]] [[https://www.tandfonline.com/doi/abs/10.1080/15384101.2018.1442626| Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N (2015) Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis. Apoptosis 20:1531–1562]] [[https://link.springer.com/article/10.1007/s10495-015-1169-2| Gambari R, Borgatti M, Lampronti I, Fabbri BE, Bianchi N, Piccagli L, Yuen MC-W, Kan C-W, Hau DK-P (2012) Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells. Int Immunopharmacol 13:308–315]] [[https://www.sciencedirect.com/science/article/pii/S156757691200118X| Garufi A, Pistritto G, Cirone M, D’Orazi G (2016) Reactivation of mutant p53 by capsaicin, the major constituent of peppers. J Exp Clin Cancer Res 35:136]] [[https://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0417-9| Georgikou C, Yin L, Gladkich J, Xiao X, Sticht C, de la Torre C, Gretz C, Gross W, Schäfer M, Karakhanova S (2020) Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer. Cancer Lett 469:238–245]] [[https://www.sciencedirect.com/science/article/pii/S0304383519305452| Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221:3–12]] [[https://onlinelibrary.wiley.com/doi/abs/10.1002/path.2697| González-Barrio R, Borges G, Mullen W, Crozier A (2010) Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J Agric Food Chem 58:3933–3939]] [[https://pubs.acs.org/doi/abs/10.1021/jf100315d| González-Bártulos M, Aceves-Luquero C, Qualai J, Cussó O, Martínez MA, de Mattos SF, Menéndez JA, Villalonga P, Costas M, Ribas X (2015) Pro-oxidant activity of amine-pyridine-based iron complexes efficiently kills cancer and cancer stem-like cells. PLoS ONE 10:e0137800]] [[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137800| González-Sarrías A, Núñez-Sánchez MÁ, Tomé-Carneiro J, Tomás-Barberán FA, García-Conesa MT, Espín JC (2016) Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved. Mol Nutr Food Res 60:701–716]] [[https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201500780| Gossner G, Choi M, Tan L, Fogoros S, Griffith KA, Kuenker M, Liu JR (2007) Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. Gynecol Oncol 105:23–30]] [[https://www.sciencedirect.com/science/article/pii/S0090825806009188| Guo L-m, Ding G-f, Xu W, Ge H, Jiang Y, Chen X-j, Lu Y (2018) MiR-135a-5p represses proliferation of HNSCC by targeting HOXA10. Cancer Biol Ther 19:973–983]] [[https://www.tandfonline.com/doi/abs/10.1080/15384047.2018.1450112| Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 15:195–218CrossRefGoogle Scholar]] [[https://link.springer.com/article/10.1208/s12248-012-9432-8| Halliwell B (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476:107–112]] [[https://www.sciencedirect.com/science/article/pii/S0003986108000489| Hargraves KG, He L, Firestone GL (2016) Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells. Mol Carcinog 55:486–498]] [[https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22296| He L, He X, Lim LP, De Stanchina E, Xuan Z, Liang Y,Xue W, Zender L, Magnus J, Ridzon D (2007) A microRNA component of the p53 tumour suppressor network. Nature 447:1130–1134]] [[https://www.nature.com/articles/nature05939| Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770–776]] [[https://www.nature.com/articles/35037710| Hermeking H (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17:193–199]] [[https://www.nature.com/articles/cdd200956| Hostanska K, Reichling J, Bommer S, Weber M, Saller R (2003) Hyperforin a constituent of St John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm 56:121–132]] [[https://www.sciencedirect.com/science/article/pii/S0939641103000468| Huang L, Li B-L, He C-X, Zhao Y-J, Yang X-L, Pang B, Zhang X-H, Shan Y-J (2018) Sulforaphane inhibits human bladder cancer cell invasion by reversing epithelial-to-mesenchymal transition via directly targeting microRNA-200c/ZEB1 axis. J Funct Foods 41:118–126]] [[https://www.sciencedirect.com/science/article/pii/S1756464617307570| Jin J, Lin G, Huang H, Xu D, Yu H, Ma X, Zhu L, Ma D, Jiang H (2014) Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. Int J Biol Sci 10:285]] [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957084/| Kim M-K, Kim K, Han JY, Lim JM, Song YS (2011) Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer. Genes Nutr 6:109–115]] [[https://link.springer.com/content/pdf/10.1007/s12263-011-0209-y.pdf| Kruk J, Aboul-Enein HY, Kładna A, Bowser JE (2019) Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis. Free Radic Res 53:497–521]] [[https://www.tandfonline.com/doi/abs/10.1080/10715762.2019.1612059| Kueck A, Opipari AW Jr, Griffith KA, Tan L, Choi M, Huang J, Wahl H, Liu JR (2007) Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol 107:450–457]] [[https://www.sciencedirect.com/science/article/pii/S0090825807005410| Kumar A, Rimando AM, Levenson AS (2017) Resveratrol and pterostilbene as a microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer. Ann N Y Acad Sci 1403:15–26]] Kumar M, Kaur V, Kumar S, Kaur S (2016) Phytoconstituents as apoptosis inducing agents: strategy to combat cancer. Cytotechnology 68:531–563 Lalaoui N, Brumatti G (2017) Relevance of necroptosis in cancer. Immunol Cell Biol 95:137–145 Lee HS, Cho HJ, Yu R, Lee KW, Chun HS, Park JHY (2014) Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. Int J Mol Sci 15:2722–2737 Lee J-C, Won S-J, Chao C-L, Wu F-L, Liu H-S, Ling P, Lin C-N, Su C-L (2008) Morusin induces apoptosis and suppresses NF-κB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun 372:236–242 Lee S, Clark R (2016) Anti-tumorigenic effects of capsaicin in colon cancer. J Food Chem Nanotechnol 2:162–167 Lee SY, Ju MK, Jeon HM, Jeong EK, Lee YJ, Kim CH, Park HG, Han SI, Kang HS (2018) Regulation of tumor progression by programmed necrosis. Oxidative Med Cell Longev 2018:3537471 Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M (2017) Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells. Theranostics 7:3461 Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, Zhao Y, Liu H, Wang J, Mei X (2017) MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma. Oncotarget 8:73938 Lim J-H, Lee Y-M, Park SR, Da Hye K, Lim BO (2014) Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells. Anticancer Res 34:4087–4093Google Scholar Lin W, Tongyi S (2014) Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells. Tumour Biol 35:8065–8075CrossRefGoogle Scholar Linder B, Kögel D (2019) Autophagy in cancer cell death. Biology 8:82CrossRefGoogle Scholar Liu RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134:3479S-3485SCrossRefGoogle Scholar Liu Z-L, Wang H, Liu J, Wang Z-X (2013) MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo-or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem 372:35–45CrossRefGoogle Scholar Ma C-H, Zhang Y-X, Tang L-H, Yang X-J, Cui W-M, Han C-C, Ji W-Y (2018) MicroRNA-1469, a p53-responsive microRNA promotes genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells. Biomed Pharmacother 106:665–671CrossRefGoogle Scholar Ma J, Cheng L, Liu H, Zhang J, Shi Y, Zeng F, Miele L, Sarkar FH, Xia J, Wang Z (2013) Genistein down-regulates miR-223 expression in pancreatic cancer cells. Curr Drug Targets 14:1150–1156CrossRefGoogle Scholar Manu K, Kuttan G (2008) Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kB mediated activation of bcl-2 in B16F–10 melanoma cells. Int Immunopharmacol 8:974–981CrossRefGoogle Scholar Melkamu T, Zhang X, Tan J, Zeng Y, Kassie F (2010) Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis 31:252–258CrossRefGoogle Scholar Mettlin C (1997) Chemoprevention: will it work? Int J Cancer 71:18–21CrossRefGoogle Scholar Miele L, Miao H, Nickoloff B (2006) NOTCH signaling as a novel cancer therapeutic target. Curr Cancer Drug Targets 6:313–323CrossRefGoogle Scholar Miki H, Uehara N, Kimura A, Sasaki T, Yuri T, Yoshizawa K, Tsubura A (2012) Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. Int J Oncol 40:1020–1028CrossRefGoogle Scholar Mishra AP, Salehi B, Sharifi-Rad M, Pezzani R, Kobarfard F, Sharifi-Rad J, Nigam M (2018) Programmed cell death, from a cancer perspective: an overview. Mol Diagn Ther 22:281–295CrossRefGoogle Scholar Mohan S, Abdelwahab SI, Kamalidehghan B, Syam S, May KS, Harmal NSM, Shafifiyaz N, Hadi AHA, Hashim NM, Rahmani M (2012) Involvement of NF-kB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine 19:1007–1015CrossRefGoogle Scholar Mousavi L, Salleh RM, Murugaiyah V (2018) Phytochemical and bioactive compounds identification of Ocimum tenuiflorum leaves of methanol extract and its fraction with an anti-diabetic potential. Int J Food Prop 21:2390–2399CrossRefGoogle Scholar Mukherjee S, Ghosh S, Das DK, Chakraborty P, Choudhury S, Gupta P, Adhikary A, Dey S, Chattopadhyay S (2015) Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection-Synthesis, characterization and in vitro evaluation. J Nutr Biochem 26:1283–1297CrossRefGoogle Scholar Mukherji SM, Singh SP (1984) Reaction mechanism in organic chemistry. Macmillan Indian Press, MadrasGoogle Scholar Munagala R, Aqil F, Vadhanam MV, Gupta RC (2013) MicroRNA ‘signature’during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. Cancer Lett 339:175–184CrossRefGoogle Scholar Nam J-S, Sharma AR, Nguyen LT, Chakraborty C, Sharma G, Lee S-S (2016) Application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine. Molecules 21:E108CrossRefGoogle Scholar Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477CrossRefGoogle Scholar Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75:311–335CrossRefGoogle Scholar Newman DJ, Cragg GM, Kingston DG (2011) Anticancer agents from natural products. CRC Press Taylor & Francis, Boca RatanGoogle Scholar Nwaeburu CC, Bauer N, Zhao Z, Abukiwan A, Gladkich J, Benner A, Herr I (2016) Up-regulation of microRNA Let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget 7:58367–58380CrossRefGoogle Scholar Oh JH, Ban JO, Cho M-C, Jo M, Jung JK, Ahn B, Yoon D-Y, Han SB, Hong JT (2012) 4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-kB activity. J Nutr Biochem 23:706–715CrossRefGoogle Scholar Omar HA, Sargeant AM, Weng J-R, Wang D, Kulp SK, Patel T, Chen C-S (2009) Targeting of the Akt-nuclear factor-kB signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. Mol Pharmacol 76:957–968CrossRefGoogle Scholar Opipari AW, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR (2004) Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 64:696–703CrossRefGoogle Scholar Park W, Amin AR, Chen ZG, Shin DM (2013) New perspectives of curcumin in cancer prevention. Cancer Prev Res 6:387–400CrossRefGoogle Scholar Purnamasari R, Winarni D, Permanasari AA, Agustina E, Hayaza S, Darmanto W (2019) Anticancer activity of methanol extract of Ficus carica leaves and fruits against proliferation, apoptosis, and necrosis in Huh7it cells. Cancer Inform 18:1176935119842576CrossRefGoogle Scholar Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014) Oxidative stress, prooxidants, and antioxidants: the interplay. BioMed Res Int 2014:761264CrossRefGoogle Scholar Rahman KW, Li Y, Sarkar FH (2004) Inactivation of Akt and NF-kB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr Cancer 48:84–94CrossRefGoogle Scholar Rao YK, Geethangili M, Fang S-H, Tzeng Y-M (2007) Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol 45:1770–1776CrossRefGoogle Scholar Ravindranath V, Chandrasekhara N (1980) Absorption and tissue distribution of curcumin in rats. Toxicology 16:259–265CrossRefGoogle Scholar Rohman A, Riyanto S, Utari D (2006) Antioxidant activities, total phenolic and flavonoid contents of ethyl acetate extract of Mengkudu (Morinda citrifolia, L) fruit and its fractions. Indones J Pharm 17:136–142Google Scholar Russo M, Spagnuolo C, Tedesco I, Russo GL (2010) Phytochemicals in cancer prevention and therapy: truth or dare? Toxins 2:517–551CrossRefGoogle Scholar Sharma K, Le N, Alotaibi M, Gewirtz DA (2014) Cytotoxic autophagy in cancer therapy. Int J Mol Sci 15:10034–10051CrossRefGoogle Scholar Slaby O, Sachlova M, Brezkova V, Hezova R, Kovarikova A, Bischofová S, Sevcikova S, Bienertova-Vasku J, Vasku A, Svoboda M (2013) Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer. Nutr Cancer 65:247–254CrossRefGoogle Scholar Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A (2015) Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients 7:4578–4592CrossRefGoogle Scholar Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP, Loizzo MR, Tundis R, Nabavi SM (2015) Genistein and cancer: current status, challenges, and future directions. Adv Nutr 6:408–419CrossRefGoogle Scholar Srinivas US, Tan BW, Vellayappan BA, Jeyasekharan AD (2019) ROS and the DNA damage response in cancer. Redox Biol 25:101084CrossRefGoogle Scholar Takada Y, Andreeff M, Aggarwal BB (2005) Indole-3-carbinol suppresses NF-kB and IkBα kinase activation, causing inhibition of expression of NF-kB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 106:641–649CrossRefGoogle Scholar Tili E, Michaille J-J (2011) Resveratrol, microRNAs, inflammation and cancer. J Nucleic Acids 2011:102431CrossRefGoogle Scholar Tse AK-W, Wan C-K, Zhu G-Y, Shen X-L, Cheung H-Y, Yang M, Fong W-F (2007) Magnolol suppresses NF-kB activation and NF-kB regulated gene expression through inhibition of IkappaB kinase activation. Mol Immunol 44:2647–2658CrossRefGoogle Scholar Tsujimoto Y, Shimizu S (2005) Another way to die: autophagic programmed cell death. Cell Death Differ 12:1528–1534CrossRefGoogle Scholar Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell B 39:44–84CrossRefGoogle Scholar Varinska L, Gal P, Mojzisova G, Mirossay L, Mojzis J (2015) Soy and breast cancer: focus on angiogenesis. Int J Mol Sci 16:11728–11749CrossRefGoogle Scholar Venkatadri R, Muni T, Iyer A, Yakisich J, Azad N (2016) Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death. Cell Death Dis 7:e2104CrossRefGoogle Scholar Vineis P, Fecht D (2018) Environment, cancer and inequalities—the urgent need for prevention. Eur J Cancer 103:317–326CrossRefGoogle Scholar Wang D-X, Zou Y-J, Zhuang X-B, Chen S-X, Lin Y, Li W-L, Lin J-J, Lin Z-Q (2017) Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacol Sin 38:241–251CrossRefGoogle Scholar Wang H, Bian S, Yang CS (2011) Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α. Carcinogenesis 32:1881–1889CrossRefGoogle Scholar Wang K, Tan S-L, Lu Q, Xu R, Cao J, Wu S-Q, Wang Y-H, Zhao X-K, Zhong Z-H (2018) Curcumin suppresses microRNA-7641-mediated regulation of p16 expression in bladder cancer. Am J Chinese Med 46:1357–1368CrossRefGoogle Scholar Wang N, Feng Y (2015) Elaborating the role of natural products-induced autophagy in cancer treatment: achievements and artifacts in the state of the art. Biomed Res Int 2015:934207Google Scholar Wang X, He H, Lu Y, Ren W, Teng K-Y, Chiang C-L, Yang Z, Yu B, Hsu S, Jacob ST (2015) Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. Biochim Biophys 185:244–253CrossRefGoogle Scholar Wei D, Yang L, Lv B, Chen L (2017) Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating miR-145 and inhibiting its target ABCE1. Mol Vis 23:385Google Scholar Weng J-R, Tsai C-H, Kulp SK, Wang D, Lin C-H, Yang H-C, Ma Y, Sargeant A, Chiu C-F, Tsai M-H (2007) A potent indole-3-carbinol–derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells. Cancer Res. 67:7815–7824CrossRefGoogle Scholar Wondrak GT (2009) Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal 11:3013–3069CrossRefGoogle Scholar Xiao D, He J (2010) Epithelial mesenchymal transition and lung cancer. J Thorac Dis 2:154–159Google Scholar Xiao X, Zhang Y, Pan W, Chen F (2020) miR-139-mediated NOTCH1 regulation is crucial for the inhibition of osteosarcoma progression caused by resveratrol. Life Sci 242:117215CrossRefGoogle Scholar Xie J, Wang J, Zhu B (2016) Genistein inhibits the proliferation of human multiple myeloma cells through suppression of nuclear factor-kB and upregulation of microRNA-29b. Mol Med Rep 13:1627–1632 Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C (2009) Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells. Cancer Lett 284:229–237CrossRefGoogle Scholar Yamada S, Tsukamoto S, Huang Y, Makio A, Kumazoe M, Yamashita S, Tachibana H (2016) Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells. Sci Rep 6:19225CrossRefGoogle Scholar Yang C, Xie X, Tang H, Dong X, Zhang X, Huang F (2018) Transcriptome analysis reveals GA induced apoptosis in HCT116 human colon cancer cells through calcium and p53 signal pathways. RSC Adv 8:12449–12458CrossRefGoogle Scholar Yang N, Zhao Y, Wang Z, Liu Y, Zhang Y (2017) Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Mol Med Rep 15:929–935CrossRefGoogle Scholar Zaman MS, Thamminana S, Shahryari V, Chiyomaru T, Deng G, Saini S, Majid S, Fukuhara S, Chang I, Arora S (2012) Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer. PLoS ONE 7:e50203CrossRefGoogle Scholar Zan L, Chen Q, Zhang L, Li X (2019) Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25. Bioengineered 10:374–382CrossRefGoogle Scholar Zaorsky NG, Churilla T, Egleston B, Fisher S, Ridge J, Horwitz E, Meyer J (2017) Causes of death among cancer patients. Ann Oncol 28:400–407CrossRefGoogle Scholar Zhang H-M, Zhao L, Li H, Xu H, Chen W-W, Tao L (2014) Research progress on the anticarcinogenic actions and mechanisms of ellagic acid. Cancer Biol Med 11:92–100Google Scholar Zhang L, Chinnathambi A, Alharbi SA, Veeraraghavan VP, Mohan SK, Zhang G (2020) Punicalagin promotes the apoptosis in human cervical cancer (ME-180) cells through mitochondrial pathway and by inhibiting the NF-kB signaling pathway. Saudi J Biol Sci 27:1100–1106CrossRefGoogle Scholar Zhang W, Bai W (2014) MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells. Clin Transl Oncol 16:708–713CrossRefGoogle Scholar Zhang X, Guo Q, Chen J, Chen Z (2015) Quercetin enhances cisplatin sensitivity of human osteosarcoma cells by modulating microRNA-217-KRAS axis. Mol Cells 38:638–642CrossRefGoogle Scholar Zhang Y, Tang L (2007) Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta Pharmacol Sin 28:1343–1354CrossRefGoogle Scholar Zhao J, Fang Z, Wang Zha Z, Sun Q, H, Sun M, Qiao B, (2019) Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer. Eur J Pharmacol 847:11–18CrossRefGoogle Scholar Zhou J, Gong J, Ding C, Chen G (2015) Quercetin induces the apoptosis of human ovarian carcinoma cells by upregulating the expression of microRNA-145. Mol Med Rep 12:3127–3131CrossRefGoogle Scholar